Sail Central America from Atlantic to Pacific
View natural beauty and an engineering marvel across the Panama Canal
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Featured Panama Canal Cruises
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10 Night Panama Canal
Carnival Legend
Departing from: Galveston, TexasPorts of Call:- Cozumel, Mexico
- Puerto Limon, Costa Rica
- Colon, Panama
- Mahogany Bay (Roatan), Bay Islands, Honduras
Sailing Dates:- October 2025
- December 2025
- March 2026
interior from$984$98pernightoceanview from$1,324$132pernightbalcony from$1,674$167pernightsuite from$3,365$337pernightRewards & Bonus Offers:Interior from $984($98pernight)3.9 rating out of 5 (2,206 reviews) -
8 Night Panama Canal
Carnival Legend
Departing from: Tampa, FloridaPorts of Call:- Puerto Limon, Costa Rica
- Colon, Panama
- George Town, Grand Cayman
Sailing Dates:- January 2027
- March 2027
interior from$1,039$130pernightoceanview from$1,189$149pernightbalcony from$1,389$174pernightsuite from$2,231$279pernightRewards & Bonus Offers:Interior from $1,039($130pernight)3.9 rating out of 5 (2,206 reviews) -
16 Night Panama Canal Carnival Journeys - Eastbound
Carnival Spirit
Departing from: Seattle, WashingtonPorts of Call:- Cabo San Lucas, Mexico
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- New Orleans, Louisiana
Sailing Dates:- October 2025
interior from$993$62pernightoceanview from$1,333$83pernightbalcony from$1,598$100pernightsuite fromCall for availabilityRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
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- Up to 2-Category Upgrade!
Interior from $993($62pernight)4 rating out of 5 (993 reviews) -
12 Night Panama Canal Discovery: Costa Rica & Greater Antilles
Rotterdam
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Relaxaway, Half Moon Cay, Bahamas (Cruiseline Private Island)
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- George Town, Grand Cayman
Sailing Dates:- October 2025
- December 2025
- February 2026
- March 2026
interior from$1,199$100pernightoceanview from$1,699$142pernightbalcony from$1,899$158pernightsuite from$2,899$242pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
- Exclusive: Up to $150 to Spend on Board - Call
- Exclusive - Free $50 Shore Excursion Coupon
- Up to 30% Savings + Up to $300 to Spend on Board
- Exclusive: Free Tamarind Dinner for 2 - Call
- No Interest or Approval: Book with No Cruise Payment Due Today
- Call for rates too low to show!
Interior from $1,199($100pernight)4.4 rating out of 5 (285 reviews) -
14 Night Panama Canal - Carnival Journeys
Carnival Venezia - Fun Italian Style!
Departing from: Port Canaveral (Orlando), FloridaPorts of Call:- Grand Turk Island, Turks & Caicos
- Oranjestad, Aruba
- Willemstad, Curacao
- Colon, Panama
- Puerto Limon, Costa Rica
- Montego Bay, Jamaica
- George Town, Grand Cayman
Sailing Dates:- January 2026
interior from$1,294$92pernightoceanview from$1,890$135pernightbalcony from$2,049$146pernightsuite fromCall for availabilityInterior from $1,294($92pernight)4.1 rating out of 5 (375 reviews) -
16 Night Panama Canal - Eastbound
Celebrity Summit
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Puerto Quetzal, Guatemala
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- Falmouth, Jamaica
- George Town, Grand Cayman
- Ft. Lauderdale (Port Everglades), Florida
Sailing Dates:- September 2025
interior from$1,562$98pernightoceanview from$1,664$104pernightbalcony from$3,554$222pernightsuite from$17,527$1,095pernightInterior from $1,562($98pernight)4.1 rating out of 5 (2,263 reviews) -
11 Night Panama Canal Partial Transit: Mexico Costa Rica & Belize
Norwegian Jewel - OPEN BAR!
Departing from: Miami, FloridaPorts of Call:- George Town, Grand Cayman
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Sailing Dates:- December 2025
- January 2026
- March 2026
interior from$1,370$125pernightoceanview from$1,470$134pernightbalcony from$2,470$225pernightsuite from$2,779$253pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
- Exclusive: Up to $200 Bonus to Spend on Board - Call
- BOGO - Second Guest Flies Free
- Exclusive - Free $50 Shore Excursion Coupon
- Save up to $150 Instantly! Call and Mention: CruiseFirst
- No Interest or Approval: Book with No Cruise Payment Due Today
Interior from $1,370($125pernight)3.7 rating out of 5 (2,423 reviews) -
12 Night Panama Canal with Costa Rica & Caribbean
Caribbean Princess
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- George Town, Grand Cayman
- Falmouth, Jamaica
- Puerto Limon, Costa Rica
- Panama Canal (Partial Transit)
- Colon, Panama
- Oranjestad, Aruba
- Willemstad, Curacao
Sailing Dates:- November 2025
- February 2026
interior from$1,398$117pernightoceanview from$1,455$121pernightbalcony from$2,296$191pernightsuite from$2,746$229pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
- Limited-Time: Book with a $1 Deposit - Must Call
- Exclusive - Free $50 Shore Excursion Coupon
- No Interest or Approval: Book with No Cruise Payment Due Today
- Spring Sale: 50% Off, $500 Instant Savings, Free Upgrades & More
- Drinks, Tips & Wi-Fi Included with Select Fares
- Call for rates too low to show!
Interior from $1,398($117pernight)3.9 rating out of 5 (1,917 reviews) -
16 Night Panama Canal - Ocean to Ocean
Caribbean Princess
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puerto Chiapas (Tapachula), Mexico
- Puntarenas, Costa Rica
- Panama City (Fuerte Amador), Panama
- Panama Canal Full Transit
- Oranjestad, Aruba
- Ft. Lauderdale (Port Everglades), Florida
Sailing Dates:- September 2025
interior from$1,562$98pernightoceanview from$1,787$112pernightbalcony from$2,512$157pernightsuite from$3,592$225pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
- Limited-Time: Book with a $1 Deposit - Must Call
- Exclusive - Free $50 Shore Excursion Coupon
- No Interest or Approval: Book with No Cruise Payment Due Today
- Spring Sale: 50% Off, $500 Instant Savings, Free Upgrades & More
- Drinks, Tips & Wi-Fi Included with Select Fares
- Call for rates too low to show!
Interior from $1,562($98pernight)3.9 rating out of 5 (1,917 reviews) -
13 Night Panama Canal Eastward
Serenade of the Seas
Departing from: San Diego, CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- Miami, Florida
Sailing Dates:- September 2025
interior from$1,595$123pernightoceanview from$2,015$155pernightbalcony from$6,646$511pernightsuite fromCall for availabilityInterior from $1,595($123pernight)4.1 rating out of 5 (1,829 reviews) -
15 Night Panama Canal: Mexico Costa Rica & Colombia
Norwegian Joy - OPEN BAR!
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Cabo San Lucas, Mexico
- Acapulco, Mexico
- Puerto Quetzal, Guatemala
- Puerto Caldera (Puntarenas), Costa Rica
- Panama City, Panama
- Panama Canal Full Transit
- Cartagena, Colombia
- Miami, Florida
Sailing Dates:- October 2025
interior from$1,671$111pernightoceanview from$2,101$140pernightbalcony from$2,851$190pernightsuite from$2,951$197pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
- Exclusive: Up to $200 Bonus to Spend on Board - Call
- BOGO - Second Guest Flies Free
- Exclusive - Free $50 Shore Excursion Coupon
- Save up to $150 Instantly! Call and Mention: CruiseFirst
- No Interest or Approval: Book with No Cruise Payment Due Today
Interior from $1,671($111pernight)4.2 rating out of 5 (994 reviews) -
11 Night Panama Canal: Mexico Costa Rica & Belize
Norwegian Pearl - OPEN BAR!
Departing from: Miami, FloridaPorts of Call:- Ocho Rios, Jamaica
- Cartagena, Colombia
- Cruise Gatun Lake And Panama Canal
- Colon, Panama
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Sailing Dates:- December 2025
- January 2026
interior from$1,662$151pernightoceanview from$2,012$183pernightbalcony from$3,112$283pernightsuite from$3,212$292pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
- Exclusive: Up to $200 to Spend on Board- Call
- Exclusive: Up to $200 Bonus to Spend on Board - Call
- BOGO - Second Guest Flies Free
- Exclusive - Free $50 Shore Excursion Coupon
- Save up to $150 Instantly! Call and Mention: CruiseFirst
Interior from $1,662($151pernight)3.8 rating out of 5 (2,072 reviews) -
12 Night Panama Canal Holiday: Costa Rica & Greater Antilles
Rotterdam
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Relaxaway, Half Moon Cay, Bahamas (Cruiseline Private Island)
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- Ocho Rios, Jamaica
Sailing Dates:- December 2025
interior from$1,799$150pernightoceanview from$2,299$192pernightbalcony from$2,599$217pernightsuite from$3,899$325pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
- Exclusive: Up to $150 to Spend on Board - Call
- Exclusive - Free $50 Shore Excursion Coupon
- Up to 30% Savings + Up to $300 to Spend on Board
- No Interest or Approval: Book with No Cruise Payment Due Today
- Free Drinks, Dining, and Excursions with Select Fares
- Call for rates too low to show!
Interior from $1,799($150pernight)4.4 rating out of 5 (285 reviews) -
12 Night Panama Canal with Costa Rica & Caribbean Holiday
Caribbean Princess
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Oranjestad, Aruba
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- George Town, Grand Cayman
Sailing Dates:- December 2025
interior from$1,898$158pernightoceanview from$2,138$178pernightbalcony from$3,098$258pernightsuite from$3,818$318pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Double points: Earn 20 points per $1 spent
- Limited-Time: Book with a $1 Deposit - Must Call
- Exclusive - Free $50 Shore Excursion Coupon
- No Interest or Approval: Book with No Cruise Payment Due Today
- Drinks, Tips & Wi-Fi Included with Select Fares
- Spring Sale: 50% Off, $500 Instant Savings, Free Upgrades & More
- Call for rates too low to show!
Interior from $1,898($158pernight)3.9 rating out of 5 (1,917 reviews) -
11 Night Panama Canal & Southern Caribbean
Celebrity Ascent
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Oranjestad, Aruba
- Willemstad, Curacao
- Kralendijk, Bonaire
Sailing Dates:- March 2026
interior from$2,489$226pernightoceanview from$2,985$271pernightbalcony from$3,604$328pernightsuite fromCall for availabilityWas $6,404 – Save up to 61%Interior from $2,489($226pernight)4.6 rating out of 5 (94 reviews) -
15 Night Panama Canal - Westbound
Radiance of the Seas
Departing from: Tampa, FloridaPorts of Call:- George Town, Grand Cayman
- Cartagena, Colombia
- Colon, Panama
- Panama Canal Full Transit
- Puerto Quetzal, Guatemala
- Puerto Vallarta, Mexico
- Los Angeles, California
Sailing Dates:- April 2025
interior from$1,491$99pernightoceanview from$1,697$113pernightbalcony fromCall for availabilitysuite fromCall for availabilityWas $3,867 – Save up to 61%Interior from $1,491($99pernight)4.2 rating out of 5 (1,299 reviews)
Discount Panama Canal Cruises
Search Panama Canal Cruises
- Azamara Cruises from $2,339
- Celebrity Cruises from $1,562
- Cunard from $2,109
- Holland America Line from $1,199
- Norwegian Cruise Line from $1,370
- Oceania Cruises from $2,325
- Ponant from $5,480
- Princess Cruises from $780
- Regent Seven Seas Cruises from $9,199
- Royal Caribbean from $1,313
- Seabourn from $5,799
- Silversea Cruises from $6,400
- Viking Ocean Cruises from $3,299
- Windstar Cruises from $2,224